Optimizing diagnosis in Parkinson's disease: Radionuclide imaging.
Identifieur interne : 000262 ( Main/Exploration ); précédent : 000261; suivant : 000263Optimizing diagnosis in Parkinson's disease: Radionuclide imaging.
Auteurs : Julieta E. Arena [Canada] ; A Jon Stoessl [Canada]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Brain (diagnostic imaging), Brain (metabolism), Diagnosis, Differential, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (metabolism), Humans, Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Positron-Emission Tomography (methods), Positron-Emission Tomography (standards), Radioisotopes (metabolism), Receptors, Dopamine (metabolism), Tomography, Emission-Computed, Single-Photon (methods), Tomography, Emission-Computed, Single-Photon (standards).
- MESH :
- chemical , metabolism : Dopamine, Dopamine Plasma Membrane Transport Proteins, Radioisotopes, Receptors, Dopamine.
- diagnostic imaging : Brain, Parkinson Disease.
- metabolism : Brain, Parkinson Disease.
- methods : Positron-Emission Tomography, Tomography, Emission-Computed, Single-Photon.
- standards : Positron-Emission Tomography, Tomography, Emission-Computed, Single-Photon.
- Animals, Diagnosis, Differential, Humans.
Abstract
Parkinson's disease (PD) and other disorders characterized by basal ganglia dysfunction are often associated with limited structural imaging changes that might assist in the clinical or research setting. Radionuclide imaging has been used to assess characteristic functional changes. Presynaptic dopaminergic dysfunction in PD can be revealed through the imaging of different steps in the process of dopamine synthesis and storage: L-aromatic amino acid decarboxylase (AADC) activity, Vesicular Monoamine Transporter type 2 (VMAT2) binding or its reuptake via the dopamine transporter (DAT). Postsynaptic dopamine dysfunction can also be studied with a variety of different tracers that primarily assess D2-like dopamine receptor availability. The function of other neurotransmitters such as norepinephrine, serotonin and acetylcholine can be imaged as well, giving important information about the underlying pathophysiologic process of PD and its complications. The imaging of metabolic activity and pathologic changes has also provided great advances in the field. Together, these techniques have allowed for a better understanding of PD, may be of aid for differentiating PD from other forms of parkinsonism and will undoubtedly be useful for the establishment of new therapeutic targets.
DOI: 10.1016/j.parkreldis.2015.09.029
PubMed: 26439947
Affiliations:
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Arena</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health</wicri:regionArea><wicri:noRegion>University of British Columbia & Vancouver Coastal Health</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Canada. 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Arena</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health</wicri:regionArea><wicri:noRegion>University of British Columbia & Vancouver Coastal Health</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name><affiliation wicri:level="1"><nlm:affiliation>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Canada. Electronic address: jstoessl@mail.ubc.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health</wicri:regionArea><wicri:noRegion>University of British Columbia & Vancouver Coastal Health</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (diagnostic imaging)</term><term>Brain (metabolism)</term><term>Diagnosis, Differential</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term><term>Humans</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (metabolism)</term><term>Positron-Emission Tomography (methods)</term><term>Positron-Emission Tomography (standards)</term><term>Radioisotopes (metabolism)</term><term>Receptors, Dopamine (metabolism)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term><term>Tomography, Emission-Computed, Single-Photon (standards)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Radioisotopes</term><term>Receptors, Dopamine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Positron-Emission Tomography</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Diagnosis, Differential</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) and other disorders characterized by basal ganglia dysfunction are often associated with limited structural imaging changes that might assist in the clinical or research setting. Radionuclide imaging has been used to assess characteristic functional changes. Presynaptic dopaminergic dysfunction in PD can be revealed through the imaging of different steps in the process of dopamine synthesis and storage: L-aromatic amino acid decarboxylase (AADC) activity, Vesicular Monoamine Transporter type 2 (VMAT2) binding or its reuptake via the dopamine transporter (DAT). Postsynaptic dopamine dysfunction can also be studied with a variety of different tracers that primarily assess D2-like dopamine receptor availability. The function of other neurotransmitters such as norepinephrine, serotonin and acetylcholine can be imaged as well, giving important information about the underlying pathophysiologic process of PD and its complications. The imaging of metabolic activity and pathologic changes has also provided great advances in the field. Together, these techniques have allowed for a better understanding of PD, may be of aid for differentiating PD from other forms of parkinsonism and will undoubtedly be useful for the establishment of new therapeutic targets.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Arena, Julieta E" sort="Arena, Julieta E" uniqKey="Arena J" first="Julieta E" last="Arena">Julieta E. Arena</name></noRegion><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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